VariantValidator Web Interface (VVweb)¶
Welcome to the VariantValidator Web Interface (VVweb) documentation.
VVweb provides an easy-to-use platform for validating, mapping, formatting and exploring human sequence variant descriptions without requiring software installation or programming knowledge.
Whether you are validating a single variant, analysing a list of variants, or identifying suitable transcript reference sequences for a gene, VVweb provides tools to support research, clinical and diagnostic workflows.".
Getting Started¶
Choose the VVweb tool that best matches your task.
Validate a single variant¶
The Validator allows you to validate a single sequence variant description interactively.
Use this tool to:
- Validate HGVS variant descriptions.
- Correct common formatting errors.
- Map variants between transcript, genomic and protein reference sequences.
- Explore detailed validation results.
Validate multiple variants¶
The Batch Validator validates multiple variant descriptions in a single submission.
Use this tool when:
- validating large variant lists;
- processing sequencing results;
- preparing supplementary data for publication; or
- validating variants prior to journal submission.
Results are processed asynchronously and returned by email.
Find transcript reference sequences¶
The Gene2Transcripts tool helps identify transcript reference sequences associated with a gene.
Use this tool to:
- discover RefSeq and Ensembl transcripts;
- identify MANE transcripts;
- obtain transcript metadata; and
- select appropriate transcripts before validating variants.
New to VariantValidator?¶
If you are unfamiliar with HGVS sequence variant nomenclature or are using VariantValidator for the first time, the following reference documentation may be helpful:
These reference pages explain accepted variant description formats, transcript selection, validation output and the meaning of validation errors and warnings generated by VariantValidator.
How to cite VariantValidator¶
If you use VariantValidator in your research, please cite the appropriate VariantValidator publication(s).
Acknowledgements¶
VariantValidator was originally developed at the University of Leicester (2016–2019). It is now maintained and developed by the University of Manchester, with continued hosting and development contributions from the University of Leicester.
